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Together, these observations lead to the conclusion that the formation of NAPQI by Cyp2E1 and the formation of protein adducts, especially on mitochondria, are initiating events leading to mitochondrial dysfunction and mitochondrial oxidant stress (Fig

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Non-heme iron content in the liver was significantly increased upon deletion of Gpx4 (Figure 6D)

From the day 5, an intraperitoneal injection of miR-125a-5p agomir, miR-125a-5p antagomir (GenePharma) or the corresponding NC (GenePharma) at 80 mg/kg was done for 3 d, and the DSS group and the normal group were given equal amounts of phosphate buffer saline (PBS) [23]

Chromosomal instability and tumors promoted by DNA hypomethylation